For the first time in his career, Rafael Nadal lost a Grand Slam match after taking a two-set lead, Associated Press reported. Furthermore, for the first time since 2004, he will end a season without winning at least one Grand Slam title.

“The only thing it means,” Nadal said about that streak coming to a close, “is I played amazing the last 10 years.”

Once so seemingly invincible, able to run down every last ball and tough to slow down once out in front, Nadal was beaten 3-6, 4-6, 6-4, 6-3, 6-4 by 32nd-seeded Fabio Fognini of Italy in the third round of the U.S. Open.

“To win like that against him, from two sets down is something incredible,” Fognini said, calling it a “mental victory.”

The eighth-seeded Nadal’s defeat, which finished at nearly 1-30 a.m. on Saturday, follows exits in the quarterfinals at the Australian Open and the French Open, then the second round at Wimbledon.

Once ranked No. 1, he dropped as low as No. 10 in 2015, his lowest spot in a decade.

The 29-year-old Spaniard also has spoken openly about a crisis of confidence, AP report pointed out.

(With inputs from AP)